Many fans continuously shout out their favorite stars to play Christian Grey and Anastasia Steele.

Some like to put Hollywood couples who already have chemistry on and off-screen. The latest couple to hit "Fifty Shades" spotlight is no other than newlyweds Ryan Reynolds and Blake Lively.

The "Fifty Shades" trilogy ("Fifty Shades of Grey," "Fifty Shades Darker," "Fifty Shades Freed"), written by bestselling author E.L. James, tells the story of 22-year-old recent college grad Anastasia Steele, who enters into a dominant/submissive sexual relationship with 27-year old sexy billionaire Christian Grey, and both explore Christian's world of BDSM while trying to understand their complicated relationship.

According to TheStirCafeMom, casting a real-life couple could really make or break the film. Fans would either love it or hate it.

"Their chemistry would likely be off the charts, simply because they've only been married for a few days, so they're smack dab in the middle of the honeymoon phase of their lives right now. That's typically the time when things are the hottest between any married couple, so if they're going to play a dominant and submissive, now might be the time to do it."

CelebsGather, however, said that Reynolds, 35, doesn't seem like the domineering type, and everyone who has seen Lively, 25, in "Gossip Girls" knows that she's not innocent?

Many fans want Lively as Kate Kavanagh anyway. Kate is Ana's best friend and roommate in the "Fifty Shades" trilogy.

There is a Twitter page,@KateK_Grey, that features Lively as the role of Kate. For Elliot Grey (Christian's brother), [SPOILER] who turns out dating Kate, a Twitter account has Reynolds as Elliot. The two accounts tweet back and forth, saying that they are a couple.

This newlywed couple has some competition though.

"Twilight" couple Kristen Stewart and Robert Pattinson was recently featured in a fan-made "Fifty Shades" trailer.

According to Gather Celebs, the video is shot and black and white. There are scenes from the original "Twilight" films, where Pattinson and Stewart star as Edward and Bella. There are a series of close-ups, followed by the make out scene in the first "Twilight" film. The words "pleasure" and "pain" flash across the screen in red letters, and the letters "S E X" come across the video as well. Pattinson and Stewart are shot with various screen shots which show smiling, sneering, brooding, and sexiness.

"Fifty Shades" first started as "Twilight" fan-fiction. Both Ana and Christian are based off Bella and Edward. The erotic novel then took a journey of its own.

Stewart was the first to wanting the role of Ana. She was, in fact, the inspiration behind Anastasia.

In May, she said she would be up for the role no matter what type it is.

But I'm dying to make another movie with Rob," Stewart in an interview with Celebuzz. "I think we're a good team, and whatever it is needs to be so ridiculously ambitious ... but I'd love to work with him again."

Another couple is Channing Tatum and his wife.

The "Magic Mike" star revealed that he would like to be 27-year-old sexy billionaire Christian Grey in July.

When asked if he would play the protagonist in the adaptation in an interview with U.K. Glamour Magazine, he responded: '1) Yes. 2) I'd only be allowed if my wife was Ana. She's read the books so I don't think she'd be impressed if she couldn't be Ana!'

Tatum's wife, Jenna Dewan-Tatum, is a professional dancer and actress who he met on the set of 2006 movie "Step Up."

Another real-life couple is "The Vampire Diaries" stars Ian Somerhalder and Nina Dobrev. Somerhalder is a huge fan favorite for Christian Grey. Dobrev might not be in the spotlight for Ana, but she has some fans under her belt.

What do you think? Should "Fifty Shades" filmmakers cast Ryan Reynolds and Blake Lively as Christian and Ana? Sound off below!

Click HERE to see who the front-runners are this week for Christian and Ana.

Click HERE to vote for Anastasia Steele!

Click HERE to vote for Christian Grey!

Vote for your favorite couples to play Ana and Christian HERE!

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